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Anti-MLH1 Monoclonal Antibody (1F378) 是一种 Mouse 抗体,靶向 MLH1。Anti-MLH1 Monoclonal Antibody (1F378) 可用于 WB,IHC,FCM。
别名 HNPCC2, HNPCC, hMLH1, FCC2, COCA2
Anti-MLH1 Monoclonal Antibody (1F378) 是一种 Mouse 抗体,靶向 MLH1。Anti-MLH1 Monoclonal Antibody (1F378) 可用于 WB,IHC,FCM。

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| 产品描述 | Anti-MLH1 Monoclonal Antibody (1F378) is a Mouse antibody targeting MLH1. Anti-MLH1 Monoclonal Antibody (1F378) can be used in WB,IHC,FCM. |
| 别名 | HNPCC2, HNPCC, hMLH1, FCC2, COCA2 |
| Ig Type | IgG1 |
| 克隆号 | 1F378 |
| 反应种属 | Human |
| 应用 | WBIHCFCM |
| 推荐剂量 | WB: 1/500-1/2000; IHC: 1/200-1/1000; FCM: 1/200-1/400 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | Hybridoma Monoclonal Antibody |
| 纯化方式 | Purified by protein A or protein G |
| 性状 | Liquid |
| 缓冲液 | PBS with 0.05% sodium azide |
| 浓度 | 1 mg/mL |
| 研究背景 | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017] |
| 偶联 | Unconjugated |
| 免疫原 | Purified recombinant fragment of human MLH1 (AA:381-483) expressed in E. Coli. |
| 抗原种属 | Human |
| 基因名称 | MLH1 |
| 基因ID | |
| 蛋白名称 | DNA mismatch repair protein Mlh1 |
| Uniprot ID |
| 分子量 | Theoretical: 84.6 kDa. |
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |