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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MICALL2/JRAB Polyclonal Antibody

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货号 TMAB-08809

Anti-MICALL2/JRAB Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MICALL2/JRAB。Anti-MICALL2/JRAB Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-MICALL2/JRAB Polyclonal Antibody

Anti-MICALL2/JRAB Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-08809

Anti-MICALL2/JRAB Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MICALL2/JRAB。Anti-MICALL2/JRAB Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

生物活性
产品描述
Anti-MICALL2/JRAB Polyclonal Antibody is a Rabbit antibody targeting MICALL2/JRAB. Anti-MICALL2/JRAB Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Cytoplasmic; cytoskeleton
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景JRAB is a 904 amino acid protein with one CH (calponin-homology) domain and one LIM zinc-binding domain. JRAB has been shown to interact with Rab13 and Rab8 to facilitate cellular transport of claudin-1, occludin, and E-cadherin. This interaction is vital for the coordination of the assembly of tight junctions (TJs) and adherens junctions (AJs). Dynamic turnover (endocytic recycling) of cell-to-cell AJs and TJs is essential for epithelial morphogenesis during normal development and differentiation. The endocytic recycling of occludin and cluadin proteins is part of an ongoing process of restructuring and maintaining cell junctions, especially at TJs. JRAb and Rab13 have also been implicated in the carcinoma metastasis event of epithelial cell scattering. This event shows Rab13 and JRAB colocalizing with F-Actin in lamellipodial structures prior to cell scattering.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MICALL2/JRAB
抗原种属
Human
基因名称
MICALL2
基因ID
79778
蛋白名称
MICAL-like protein 2
Uniprot ID
Q8IY33
功能
Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth.
化学信息
分子量Theoretical: 55 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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