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顶部生物活性储存和溶解信息计算器

Anti-MERTK/Mer Antibody (2J614)

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Anti-MERTK/Mer Antibody (2J614)
产品编号 TMAH-00746
别名 Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk

Anti-MERTK/Mer Antibody (2J614) 是一种抗体，靶向 MERTK/Mer。Anti-MERTK/Mer Antibody (2J614) 可用于 ELISA。

Anti-MERTK/Mer Antibody (2J614)

Anti-MERTK/Mer Antibody (2J614)

Rating icon 还可以
Anti-MERTK/Mer Antibody (2J614)
产品编号 TMAH-00746 别名 Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk

Anti-MERTK/Mer Antibody (2J614) 是一种抗体，靶向 MERTK/Mer。Anti-MERTK/Mer Antibody (2J614) 可用于 ELISA。

规格价格库存数量
50 μL
¥ 1,310
5日内发货
100 μL
¥ 2,180
5日内发货
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产品介绍

生物活性
产品描述
Anti-MERTK/Mer Antibody (2J614) is an antibody targeting MERTK/Mer. Anti-MERTK/Mer Antibody (2J614) can be used in ELISA.
别名Tyro12, RP38, MGC133349, MERTK, MER, c-mer, c-Eyk
Ig Type
Human IgG4(S228P)
克隆号
2J614
交叉反应
Human
验证活性
The Binding Activity of MERTK with anti-MERTK antibody.
Activity: Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 μg/mL can bind anti-MERTK antibody(TMAH-00746), the EC50 is 41.31-72.08 ng/mL.
应用
ELISA
抗体种类
Monoclonal
亚细胞定位Membrane; Single-pass type I membrane protein.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human MERTK Protein
抗原种属
Human
基因ID
10461
Uniprot ID
Q12866
研究领域
Neuroscience, Signal transduction
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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关键词

RP-38RP 38MGC-133349MGC 133349

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