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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MeCP2 Polyclonal Antibody 2

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货号 TMAB-08701

Anti-MeCP2 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 MeCP2。Anti-MeCP2 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

Anti-MeCP2 Polyclonal Antibody 2

Anti-MeCP2 Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-08701

Anti-MeCP2 Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 MeCP2。Anti-MeCP2 Polyclonal Antibody 2 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-MeCP2 Polyclonal Antibody 2 is a Rabbit antibody targeting MeCP2. Anti-MeCP2 Polyclonal Antibody 2 can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Note=Colocalized with methyl-CpG in the genome.
组织特异性Present in all adult somatic tissues tested.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3 and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of some cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MeCP2
抗原种属
Human
基因名称
MECP2
基因ID
4204
蛋白名称
Methyl-CpG-binding protein 2
Uniprot ID
P51608
功能
Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3A.
化学信息
分子量Theoretical: 52 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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