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Anti-MDFIC Polyclonal Antibody

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货号 TMAB-08687

Anti-MDFIC Polyclonal Antibody 是一种 Rabbit 抗体,靶向 MDFIC。Anti-MDFIC Polyclonal Antibody 可用于 WB。

Anti-MDFIC Polyclonal Antibody

Anti-MDFIC Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-08687

Anti-MDFIC Polyclonal Antibody 是一种 Rabbit 抗体,靶向 MDFIC。Anti-MDFIC Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍


生物活性
产品描述
Anti-MDFIC Polyclonal Antibody is a Rabbit antibody targeting MDFIC. Anti-MDFIC Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Nucleus, nucleolus. Note=Also shows a granular distribution in the cytoplasm. Isoform 2: Cytoplasm. Note=Weak expression in the nucleus.
组织特异性Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MDFIC
抗原种属
Human
基因名称
MDFIC
基因ID
蛋白名称
MyoD family inhibitor domain-containing protein
Uniprot ID
功能
Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.
化学信息
分子量Theoretical: 26 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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