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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-MARCH9 Polyclonal Antibody

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货号 TMAB-08612

Anti-MARCH9 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MARCH9。Anti-MARCH9 Polyclonal Antibody 可用于 WB,FCM。

Anti-MARCH9 Polyclonal Antibody

Anti-MARCH9 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-08612

Anti-MARCH9 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MARCH9。Anti-MARCH9 Polyclonal Antibody 可用于 WB,FCM。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-MARCH9 Polyclonal Antibody is a Rabbit antibody targeting MARCH9. Anti-MARCH9 Polyclonal Antibody can be used in WB,FCM.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1μg/Test
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.
组织特异性Ubiquitously expressed.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH9 (membrane-associated ring finger (C3HC4) 9), also known as RNF179, is a 346 amino acid multi-pass membrane protein that localizes to the golgi apparatus and contains one RING-CH-type zinc finger. Expressed ubiquitously, MARCH9 exists as a homodimer and functions as an E3 ubiquitin-protein ligase that accepts a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and is thought to promote the degradation of target proteins, such as CD4 and MHC-I. Multiple isoforms of MARCH9 exist due to alternative splicing events.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MARCH9
抗原种属
Human
基因名称
MARCHF9
基因ID
92979
蛋白名称
E3 ubiquitin-protein ligase MARCHF9
Uniprot ID
Q86YJ5
功能
E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
化学信息
分子量Theoretical: 38 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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