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Anti-MAL2 Polyclonal Antibody

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货号 TMAB-01096

别名 Mal, T cell differentiation protein 2, MAL proteolipid protein 2, MAL 2

Anti-MAL2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MAL2。Anti-MAL2 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-MAL2 Polyclonal Antibody

Anti-MAL2 Polyclonal Antibody

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货号 TMAB-01096 别名 Mal, T cell differentiation protein 2, MAL proteolipid protein 2, MAL 2

Anti-MAL2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 MAL2。Anti-MAL2 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-MAL2 Polyclonal Antibody is a Rabbit antibody targeting MAL2. Anti-MAL2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名Mal, T cell differentiation protein 2, MAL proteolipid protein 2, MAL 2
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Pig,Cow)
验证活性
Paraformaldehyde-fixed, paraffin embedded (human liver carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (MAL2) Polyclonal Antibody, Unconjugated (TMAB-01096) at 1:400 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
verifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Apical cell membrane. Endomembrane system. Cytoplasm > perinuclear region. Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma HepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized HepG2 cells, distributed to the perinuclear region.
组织特异性Predominantly expressed in kidney, lung, and liver. Also found in thyroid gland, stomach and, at lower levels in testis and small intestine.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景The MARVEL domain is a 130 amino acid motif that contains four transmembrane helices, both of which have cytoplasmic N- and C-terminal regions. MARVEL domain-containing proteins are thought to participate in tight junction regulation, the biogenesis of vesicular transport carriers and in cholesterol-rich membrane apposition events. MAL2 (mal, T-cell differentiation protein 2) is a 176 amino acid multi-pass membrane protein that is associated with lipid rafts and contains one MARVEL domain. Expressed predominately in liver, kidney and lung, MAL2 functions as a member of the polarized machinery transport system and is required for transcytosis, a transporter pathway used to deliver membrane-bound cargo from perinuclear endosomes to the apical surface in a raft-dependent manner. Differential expression of MAL2 is associated with several cancers, including renal cell carcinoma and childhood leukemia, suggesting a role for MAL2 in tumorigensis.
抗原信息
免疫原
KLH conjugated synthetic peptide: human MAL2
抗原种属
Human
基因名称
MAL2
基因ID
114569
蛋白名称
Protein MAL2
Uniprot ID
Q969L2
研究领域
Lipid metabolism,Regulation
功能
Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway.
化学信息
分子量Theoretical: 19 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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