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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Mafa Polyclonal Antibody 2

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货号 TMAB-08506

Anti-Mafa Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Mafa。Anti-Mafa Polyclonal Antibody 2 可用于 WB。

Anti-Mafa Polyclonal Antibody 2

Anti-Mafa Polyclonal Antibody 2

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Rating icon 还可以
货号 TMAB-08506

Anti-Mafa Polyclonal Antibody 2 是一种 Rabbit 抗体，靶向 Mafa。Anti-Mafa Polyclonal Antibody 2 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-Mafa Polyclonal Antibody 2 is a Rabbit antibody targeting Mafa. Anti-Mafa Polyclonal Antibody 2 can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Chicken,Pig,Cow)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus. Note=Detected in nuclei of pancreas islet beta cells.
组织特异性Selectively expressed in pancreatic beta but not in alpha cells (at protein level). Expressed in eyes and at low levels in thymus. Expressed in brain, lung, spleen and kidney. Expressed in embryo.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Insulin gene expression is regulated by several islet-enriched transcription factors. However, MAFA is the only beta cell-specific activator. MAFA selectively induces endogenous insulin transcription in non-beta cells. MAFA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MAFA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Mafa
抗原种属
Human
基因名称
MAFA
基因ID
389692
蛋白名称
Transcription factor MafA
Uniprot ID
Q8NHW3
功能
Acts as a transcriptional factor. Specifically binds the insulin enhancer element RIPE3b. Cooperates synergistically with NEUROD1 and PDX1. Phosphorylation by GSK3 increases its transcriptional activity and is required for its oncogenic activity. Regulates the insulin gene transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context.
化学信息
分子量Theoretical: 37 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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