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Anti-MAD2L1 Antibody (2Y202)
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产品编号 TMAC-02444
别名 MAD2 mitotic arrest deficient-like 1 (yeast), MAD2, HSMAD2
Anti-MAD2L1 Antibody (2Y202) 是一种 Rabbit 抗体，靶向 MAD2L1。Anti-MAD2L1 Antibody (2Y202) 可用于 WB,ICC。
Anti-MAD2L1 Antibody (2Y202)
Anti-MAD2L1 Antibody (2Y202)
还可以产品编号 TMAC-02444 别名 MAD2 mitotic arrest deficient-like 1 (yeast), MAD2, HSMAD2
Anti-MAD2L1 Antibody (2Y202) 是一种 Rabbit 抗体，靶向 MAD2L1。Anti-MAD2L1 Antibody (2Y202) 可用于 WB,ICC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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| 产品描述 | Anti-MAD2L1 Antibody (2Y202) is a Rabbit antibody targeting MAD2L1. Anti-MAD2L1 Antibody (2Y202) can be used in WB,ICC. |
| 别名 | MAD2 mitotic arrest deficient-like 1 (yeast), MAD2, HSMAD2 |
| Ig Type | IgG |
| 交叉反应 | Human |
| 验证活性 | 1. Western blot analysis of Mad2L1 on different cell lysates using anti-Mad2L1 antibody at 1/500 dilution. Positive control: Lane 1: K562, Lane 2: 293T, Lane 3: SH-SY5Y. 2. ICC staining Mad2L1 in SH-SY5Y cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:500-2000; ICC: 1:100-500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD2 (for mitotic arrest-deficient) is a component of the mitotic spindle checkpoint. Cells with mutated MAD2 do not undergo mitotic arrest in response to incorrect spindle fiber assembly, which results in missegregation and eventual cell death. A breast carcinoma cell line with reduced MAD2 expression, T47D, was shown to complete mitosis in the presence of nocodazole, an inhibitor of mitotic spindle assembly. MAD2 is localized to unattached kinetochores during prometaphase and disassociates upon spindle fiber attachment, indicating that MAD2 regulates kinetochore binding to the spindle fibers. Human MAD2 has also been shown to associate with insulin receptor (IR), but not IGFIR, implicating MAD2 as a mediator for IR-specific signaling. MAD2B, a MAD2 homolog, is required for the execution of the mitotic checkpoint monitoring the kinetochore-spindle attachment process and if the process is not complete, MAD2B delays the onset of anaphase. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 23.5 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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