Anti-LRP1 Polyclonal Antibody is a Rabbit antibody targeting LRP1. Anti-LRP1 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P,WB.

IgG

Human (predicted:Dog,Pig,Cow,Rabbit,Sheep)

1. Sample:
Lane 1: A549 (Human) Cell Lysate at 30 μg
Lane 2: HepG2 (Human) Cell Lysate at 30 μg
Lane 3: U2os (Human) Cell Lysate at 30 μg
Primary: Anti-LRP1 (TMAB-01082) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 85 kDa
Observed band size: 85 kDa
2. Paraformaldehyde-fixed, paraffin embedded (human brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (LRP1) Polyclonal Antibody, Unconjugated (TMAB-01082) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.

WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500

Polyclonal

KLH conjugated synthetic peptide: human LRP1

Human

LRP1

Prolow-density lipoprotein receptor-related protein 1

Metabolism,Phagocytosis,Lipoprotein metabolism,Serum Proteins,Cholesterol Metabolism,Phagocytosis,Cholesterol Metabolism,Lipoprotein metabolism,Apoptosis,Cancer,Heart disease,Neurodegenerative disease,Obesity,Alzheimer's disease,Lipid metabolism

Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission.
Functions as a receptor for Pseudomonas aeruginosa exotoxin A.