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Anti-LIN28B Antibody (6R683)

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货号 TMAB-08318

Anti-LIN28B Antibody (6R683) 是一种 Rabbit 抗体，靶向 LIN28B。Anti-LIN28B Antibody (6R683) 可用于 WB,ICC/IF,IP,FCM。

Anti-LIN28B Antibody (6R683)

Anti-LIN28B Antibody (6R683)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08318

Anti-LIN28B Antibody (6R683) 是一种 Rabbit 抗体，靶向 LIN28B。Anti-LIN28B Antibody (6R683) 可用于 WB,ICC/IF,IP,FCM。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-LIN28B Antibody (6R683) is a Rabbit antibody targeting LIN28B. Anti-LIN28B Antibody (6R683) can be used in WB,ICC/IF,IP,FCM.
Ig Type
IgG
克隆号
6R683
反应种属
Human
应用WBICC/IFIPFCM
推荐剂量
WB: 1:500-2000; ICC/IF: 1:50-200; IP: 1:20-50; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Predominantly cytoplasmic at G1 phase, accumulates in the nucleus in S and G2 phases. The frequency of nuclear localization in S and in G2 phases is 60% and 30%, respectively.
组织特异性High expression in testis, fetal liver, placenta and in hepatocellular carcinoma (HCC). Isoform 1 is only detected in moderately and poorly differentiated HCC tissues and placenta (at protein level). Isoform 2 is detected in fetal liver, non-tumor liver tissues, as well as well-differentiated tumor tissues (at protein level).
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA.
抗原信息
免疫原
A synthesized peptide: human Lin 28B
抗原种属
Human
基因名称
LIN28B
基因ID
389421
蛋白名称
Protein lin-28 homolog B
Uniprot ID
Q6ZN17
功能
Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
化学信息
分子量Theoretical: 27 kDa. Actual: 30 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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