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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-LIMK1 Antibody (2K696)

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货号 TMAB-08314

Anti-LIMK1 Antibody (2K696) 是一种 Rabbit 抗体，靶向 LIMK1。Anti-LIMK1 Antibody (2K696) 可用于 WB。

Anti-LIMK1 Antibody (2K696)

Anti-LIMK1 Antibody (2K696)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08314

Anti-LIMK1 Antibody (2K696) 是一种 Rabbit 抗体，靶向 LIMK1。Anti-LIMK1 Antibody (2K696) 可用于 WB。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,495
5日内发货
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产品介绍

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产品描述
Anti-LIMK1 Antibody (2K696) is a Rabbit antibody targeting LIMK1. Anti-LIMK1 Antibody (2K696) can be used in WB.
Ig Type
IgG
克隆号
2K696
反应种属
Human (predicted:Rat,Mouse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm.
组织特异性Highest expression in both adult and fetal nervous system. Detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex. Expressed to a lesser extent in heart and skeletal muscle.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways.Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop.
抗原信息
免疫原
A synthesized peptide: human LIMK 1
抗原种属
Human
基因名称
LIMK1
基因ID
3984
蛋白名称
LIM domain kinase 2
Uniprot ID
P53667
功能
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development. Isoform 3 has a dominant negative effect on actin cytoskeletal changes.
化学信息
分子量Theoretical: 73 kDa. Actual: 72 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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