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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-LIM kinase 2 Polyclonal Antibody

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货号 TMAB-08309

Anti-LIM kinase 2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 LIM kinase 2。Anti-LIM kinase 2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-LIM kinase 2 Polyclonal Antibody

Anti-LIM kinase 2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-08309

Anti-LIM kinase 2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 LIM kinase 2。Anti-LIM kinase 2 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,160
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100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-LIM kinase 2 Polyclonal Antibody is a Rabbit antibody targeting LIM kinase 2. Anti-LIM kinase 2 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Isoform LIMK2a is distributed in the cytoplasm and the nucleus and Cytoplasm. Nucleus. Isoform LIMK2b occurs mainly in the cytoplasm and is scarcely translocated to the nucleus.
组织特异性Highest expression in the placenta; moderate level in liver, lung, kidney, and pancreas. LIMK2a is found to be more abundant then LIMK2b in liver, colon, stomach, and spleen, while in brain, kidney, and placenta LIMK2b is the dominant form. In adult lung, both LIMK2a and LIMK2b is nearly equally observed.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
抗原信息
免疫原
KLH conjugated synthetic peptide: human LIM kinase 2
抗原种属
Human
基因名称
LIMK2
基因ID
3985
蛋白名称
LIM domain kinase 2
Uniprot ID
P53671
功能
Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro.
化学信息
分子量Theoretical: 72 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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