Name: Anti-LILRB4/ILT3/CD85k Antibody
Brand: TargetMol
SKU: T9901A-1430
Rating: 4.5 (1 reviews)

生物活性

产品描述	Anti-LILRB4/ILT3/CD85k Antibody is a potent monoclonal antibody targeting the inhibitory receptor LILRB4, acting by blocking the binding of LILRB4 to its ligands such as APOE. The compound is an essential tool for investigating myeloid immune checkpoints, immune escape in acute myeloid leukemia (AML), and mechanisms of immune tolerance induction, aiming to restore the anti-tumor activity of effector T cells by lifting LILRB4-mediated signaling inhibition.
体外活性	在人单核细胞型 AML 细胞系（如 MV4-11）中，Anti-LILRB4/ILT3/CD85k Antibody (h12F6) 阻断了 APOE 与 LILRB4 的结合并抑制了 SHP-1 募集 [1]。
体内活性	在人 AML 异种移植模型中，通过全身给药方式给予 Anti-LILRB4/ILT3/CD85k Antibody (h12F6)，显著减少了白血病细胞向肝脏和脑部的浸润 [1]。
别名	抗LILRB4/ILT3/CD85k 抗体
反应种属	Human
应用	ELISA FACS Functional assay
抗体种类	Monoclonal
缓冲液	Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
内毒素	<1.0 EU/mg

抗体信息

同型

IgG1

偶联与修饰

偶联	Unconjugated

抗原信息

Uniprot ID	Q8NHJ6
靶点	LILRB4/IL-T3/CD85k

储存&溶解度

存储

Anti-LILRB4/ILT3/CD85k Antibody