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Anti-LGR5/GPR49 Antibody (1W324)

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货号 TMAB-08292

Anti-LGR5/GPR49 Antibody (1W324) 是一种 Rabbit 抗体,靶向 LGR5/GPR49。Anti-LGR5/GPR49 Antibody (1W324) 可用于 WB,FCM。

Anti-LGR5/GPR49 Antibody (1W324)

Anti-LGR5/GPR49 Antibody (1W324)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08292

Anti-LGR5/GPR49 Antibody (1W324) 是一种 Rabbit 抗体,靶向 LGR5/GPR49。Anti-LGR5/GPR49 Antibody (1W324) 可用于 WB,FCM。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍


生物活性
产品描述
Anti-LGR5/GPR49 Antibody (1W324) is a Rabbit antibody targeting LGR5/GPR49. Anti-LGR5/GPR49 Antibody (1W324) can be used in WB,FCM.
Ig Type
IgG
克隆号
1W324
反应种属
Human,Mouse,Rat
应用WBFCM
推荐剂量
WB: 1:500-2000; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Multi-pass membrane protein.
组织特异性Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究背景The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
抗原信息
免疫原
A synthesized peptide: human LGR5
抗原种属
Human
基因名称
LGR5
基因ID
蛋白名称
Leucine-rich repeat-containing G-protein coupled receptor 5
Uniprot ID
功能
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development.
化学信息
分子量Theoretical: 98 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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