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Anti-LGR5/GPR49 Antibody (1W324) 是一种 Rabbit 抗体,靶向 LGR5/GPR49。Anti-LGR5/GPR49 Antibody (1W324) 可用于 WB,FCM。
Anti-LGR5/GPR49 Antibody (1W324) 是一种 Rabbit 抗体,靶向 LGR5/GPR49。Anti-LGR5/GPR49 Antibody (1W324) 可用于 WB,FCM。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μL | ¥ 790 | 5日内发货 | |
| 50 μL | ¥ 1,385 | 5日内发货 | |
| 100 μL | ¥ 2,485 | 5日内发货 |
| 产品描述 | Anti-LGR5/GPR49 Antibody (1W324) is a Rabbit antibody targeting LGR5/GPR49. Anti-LGR5/GPR49 Antibody (1W324) can be used in WB,FCM. |
| Ig Type | IgG |
| 克隆号 | 1W324 |
| 反应种属 | Human,Mouse,Rat |
| 应用 | WBFCM |
| 推荐剂量 | WB: 1:500-2000; FCM: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Cell membrane; Multi-pass membrane protein. |
| 组织特异性 | Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究背景 | The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015] |
| 免疫原 | A synthesized peptide: human LGR5 |
| 抗原种属 | Human |
| 基因名称 | LGR5 |
| 基因ID | |
| 蛋白名称 | Leucine-rich repeat-containing G-protein coupled receptor 5 |
| Uniprot ID | |
| 功能 | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. |
| 分子量 | Theoretical: 98 kDa. |
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
| 存储 | store at low temperature | -20°C for 1 year |