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Anti-LDLR Antibody (6L836)

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货号 TMAB-08263

Anti-LDLR Antibody (6L836) 是一种 Rabbit 抗体，靶向 LDLR。Anti-LDLR Antibody (6L836) 可用于 IHC-P,IHC-Fr,IF。

Anti-LDLR Antibody (6L836)

Anti-LDLR Antibody (6L836)

一键复制产品信息
Rating icon 还可以
货号 TMAB-08263

Anti-LDLR Antibody (6L836) 是一种 Rabbit 抗体，靶向 LDLR。Anti-LDLR Antibody (6L836) 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,395
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-LDLR Antibody (6L836) is a Rabbit antibody targeting LDLR. Anti-LDLR Antibody (6L836) can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
克隆号
6L836
反应种属
Human,Mouse
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Note=Found distributed from the plasma membrane to intracellular compartments.
组织特异性Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 0.05% BSA, 40% Glycerol, 0.02% Proclin300.
浓度1mg/ml
研究背景The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
抗原信息
免疫原
A synthesized peptide: human LDL receptor
抗原种属
Human
基因名称
LDLR
基因ID
3949
蛋白名称
Low-density lipoprotein receptor
Uniprot ID
P01130
功能
Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells.
化学信息
分子量Theoretical: 92 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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