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顶部生物活性储存和溶解信息计算器

Anti-LAG3 Antibody (5Y626)

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产品编号 TMAH-00682

别名 lymphocyte-activation gene 3, LAG-3, CD223

Anti-LAG3 Antibody (5Y626) 是一种抗体，靶向 LAG3。Anti-LAG3 Antibody (5Y626) 可用于 ELISA,IHC。

Anti-LAG3 Antibody (5Y626)

Anti-LAG3 Antibody (5Y626)

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产品编号 TMAH-00682 别名 lymphocyte-activation gene 3, LAG-3, CD223

Anti-LAG3 Antibody (5Y626) 是一种抗体，靶向 LAG3。Anti-LAG3 Antibody (5Y626) 可用于 ELISA,IHC。

规格价格库存数量
50 μL
¥ 1,300
5日内发货
100 μL
¥ 2,195
5日内发货
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产品介绍

生物活性
产品描述
Anti-LAG3 Antibody (5Y626) is an antibody targeting LAG3. Anti-LAG3 Antibody (5Y626) can be used in ELISA,IHC.
别名lymphocyte-activation gene 3, LAG-3, CD223
Ig Type
hIgG1
克隆号
5Y626
交叉反应
Human
验证活性
1. IHC image of TMAH-00682 diluted at 1：100 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-human polymer IgG labeled by HRP and visualized using 0.05% DAB.
2. The Binding Activity of Human LAG3 with Anti-LAG3 Recombinant Antibody
Activity: Measured by its binding ability in a functional ELISA. Immobilized Human LAG3 at 2 μg/mL can bind Anti-LAG3 recombinant antibody. The EC50 is 2.306-2.731 ng/mL.
应用ELISAIHC
推荐剂量
IHC:1:50-1:200.
抗体种类
Monoclonal
亚细胞定位[Lymphocyte activation gene 3 protein]: Cell membrane; Single-pass type I membrane protein.; [Secreted lymphocyte activation gene 3 protein]: Secreted.
组织特异性Primarily expressed in activated T-cells and a subset of natural killer (NK) cells.
构建方式Recombinant Antibody
纯化方式Affinity-chromatography
性状Liquid
缓冲液Preservative: 0.03% Proclin 300. Constituents: 50% Glycerol, 0.01M PBS, PH 7.4.
研究背景Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with CD3-TCR in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear. May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein: Human LAG3 Protein
抗原种属
Human
基因名称
LAG3
基因ID
3902
Uniprot ID
P18627
研究领域
Immunology
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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关键词

LAG3LAG 3CD-223CD 223

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