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Anti-L-selectin Antibody (5Y880)
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产品编号 TMAY-03059
别名 selectin L
Anti-L-selectin Antibody (5Y880) 是一种 Rabbit 抗体，靶向 L-selectin。Anti-L-selectin Antibody (5Y880) 可用于 FCM,ICC/IF。
Anti-L-selectin Antibody (5Y880)
331 Anti-L-selectin Antibody (5Y880)
还可以产品编号 TMAY-03059 别名 selectin L
Anti-L-selectin Antibody (5Y880) 是一种 Rabbit 抗体，靶向 L-selectin。Anti-L-selectin Antibody (5Y880) 可用于 FCM,ICC/IF。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 2,279 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-L-selectin Antibody (5Y880) is a Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody (5Y880) can be used in FCM,ICC/IF. |
| 别名 | selectin L |
| Ig Type | Rabbit IgG |
| 克隆号 | 5Y880 |
| 交叉反应 | Mouse |
| 验证活性 | 1. Immunofluorescence staining of mouse SELL in mouse splenocytes. Cells were fixed with 4% PFA, blocked with 10% serum, and incubated with rabbit anti-mouse SELL monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 594-conjugated Goat Anti-rabbit IgG secondary antibody (red). 2. Flow cytometric analysis of Mouse CD62L expression on BABL/c splenocytes. Cells were stained with purified anti-Mouse CD62L, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| 应用 | FCM,ICC/IF |
| 推荐剂量 | ICC-IF: 1:20-1:100; FCM: 1:25-1:100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD62L / L-Selectin (rM CD62L / L-Selectin; TMPY-01184; NP_035476.1; Met1-Asn332). |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| 偶联 | Unconjugated |
| 其他可选修饰符 | APC/PerCP/FITC/PE |
| 可提供抗体种类 | 5 |
| 免疫原 | Recombinant Protein: Mouse CD62L / L-Selectin Protein (TMPY-01184) |
| 抗原种属 | Mouse |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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