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顶部生物活性储存和溶解信息计算器

Anti-KRT8/18 Antibody (6E645)

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Anti-KRT8/18 Antibody (6E645)
产品编号 TMAC-01097
别名 KO, K8, K2C8, Cytokeratin8, CYK8, CK-8, CK8, CARD2

Anti-KRT8/18 Antibody (6E645) 是一种 Rabbit 抗体，靶向 KRT8/18。Anti-KRT8/18 Antibody (6E645) 可用于 WB,ICC/IF,IHC,IP,FCM。

Anti-KRT8/18 Antibody (6E645)

Anti-KRT8/18 Antibody (6E645)

Rating icon 还可以
Anti-KRT8/18 Antibody (6E645)
产品编号 TMAC-01097 别名 KO, K8, K2C8, Cytokeratin8, CYK8, CK-8, CK8, CARD2

Anti-KRT8/18 Antibody (6E645) 是一种 Rabbit 抗体，靶向 KRT8/18。Anti-KRT8/18 Antibody (6E645) 可用于 WB,ICC/IF,IHC,IP,FCM。

规格价格库存数量
50 μL
¥ 1,480
5日内发货
100 μL
¥ 2,485
5日内发货
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产品介绍

生物活性
产品描述
Anti-KRT8/18 Antibody (6E645) is a Rabbit antibody targeting KRT8/18. Anti-KRT8/18 Antibody (6E645) can be used in WB,ICC/IF,IHC,IP,FCM.
别名KO, K8, K2C8, Cytokeratin8, CYK8, CK-8, CK8, CARD2
Ig Type
IgG
交叉反应
Human,Mouse
验证活性
1. Western blot analysis of Cytokeratin 8+18 on different lysates using anti-Cytokeratin 8+18 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela, Lane 2: MCF-7, Lane 3: A431.
2. Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-Cytokeratin 8+18 antibody. Counter stained with hematoxylin.
3. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-Cytokeratin 8+18 antibody. Counter stained with hematoxylin.
4. ICC staining Cytokeratin 8+18 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
5. ICC staining Cytokeratin 8+18 in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
6. ICC staining Cytokeratin 8+18 in A431 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.
7. Flow cytometric analysis of Hela cells with Cytokeratin 8+18 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.
应用
WB
ICC/IF
IHC
IP
FCM
推荐剂量
WB: 1:1000-2000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:50-100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式Recombinant Antibody
纯化方式ProA affinity purified
性状Liquid
缓冲液1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
研究背景Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. They have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratin 8 expression is seen in epithelium and epithelium-derived tumors. The Cytokeratin 8 and 18 pair are normally expressed in simple epithelia, but not in stratified epithelial cells. Research indicates that squamous cell carcinomas derived from stratified epithelia show abnormal expression of Cytokeratin 8 and 18, although it is not known whether these proteins contribute to the malignant phenotype of the cells. Expression of Cytokeratin 8 and 18 in oral squamous cell carcinomas is an independent prognostic marker that indicates a poor prognosis. Cytokeratin 8 expression correlates with malignancy in leukoplakia and carcinomas of the head and neck; it is expressed in all non-small-cell lung cancers. Cytokeratin 8 has been shown to possess extracellular epitopes on tumor cells, which may represent valuable targets for therapy.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Recombinant Protein
化学信息
分子量Theoretical: 53 kDa.
存储&运输
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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