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Anti-KIRREL3 Antibody (4I945)
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产品编号 TMAY-03782
别名 kin of IRRE like 3 (Drosophila)
Anti-KIRREL3 Antibody (4I945) 是一种 Mouse 抗体，靶向 KIRREL3。Anti-KIRREL3 Antibody (4I945) 可用于 ELISA。
Anti-KIRREL3 Antibody (4I945)
Anti-KIRREL3 Antibody (4I945)
还可以产品编号 TMAY-03782 别名 kin of IRRE like 3 (Drosophila)
Anti-KIRREL3 Antibody (4I945) 是一种 Mouse 抗体，靶向 KIRREL3。Anti-KIRREL3 Antibody (4I945) 可用于 ELISA。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 100 μL | ¥ 1,684 | 5日内发货 |
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抗原信息
| 产品描述 | Anti-KIRREL3 Antibody (4I945) is a Mouse antibody targeting KIRREL3. Anti-KIRREL3 Antibody (4I945) can be used in ELISA. |
| 别名 | kin of IRRE like 3 (Drosophila) |
| Ig Type | Mouse IgG1 |
| 克隆号 | 4I945 |
| 交叉反应 | Rat |
| 应用 | |
| 推荐剂量 | ELISA: 1:1000-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Rat KIRREL3 / NEPH2 (TMPY-03241; Q09GS6; Met1-Ala523). The IgG fraction of the cell culture supernatant was purified by Protein A affinity. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | Kin of IRRE-like protein 3 (KIRREL3) also known as nin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a member of the nephrin-like protein family of transmembrane proteins, which includes NEPH1 (KIRREL) and NEPH3 (KIRREL2). KIRREL3/NEPH2 is expressed in the fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of KIRREL3/NEPH2 interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in KIRREL3/NEPH2 are associated with mental retardation autosomal dominant type 4. KIRREL3/NEPH2 expression is turned on in migrating Nucleogenesis of the pontine nucleus (PN) neurons only after they enter the presumptive nuclear region. KIRREL3/NEPH2 knockdown disrupted the nuclear organization of PN presumably by changing the migratory behavior of PN neurons inside the nuclear region. Moreover, overexpression of the cytoplasmic region of KIRREL3, which can sequester intracellular signaling of endogenous KIRREL3, resulted in similar phenotypes. Overall, these results suggest KIRREL3 is involved in the Nucleogenesis of the PN through the control of neuronal migration inside the nucleus. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein: Rat KIRREL3 / NEPH2 protein (TMPY-03241) |
| 抗原种属 | Rat |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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