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Anti-Ki67/MKI67 Antibody (4X112)
还可以产品编号 TMAY-00075
Anti-Ki67/MKI67 Antibody (4X112) 是一种 Mouse 抗体，靶向 Ki67/MKI67。Anti-Ki67/MKI67 Antibody (4X112) 可用于 IHC-P。
Anti-Ki67/MKI67 Antibody (4X112)
Anti-Ki67/MKI67 Antibody (4X112)
还可以产品编号 TMAY-00075
Anti-Ki67/MKI67 Antibody (4X112) 是一种 Mouse 抗体，靶向 Ki67/MKI67。Anti-Ki67/MKI67 Antibody (4X112) 可用于 IHC-P。
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| 产品描述 | Anti-Ki67/MKI67 Antibody (4X112) is a Mouse antibody targeting Ki67/MKI67. Anti-Ki67/MKI67 Antibody (4X112) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 4X112 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human KI-67 in human breast carcinoma with mouse monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human KI-67 in human lung cancer with mouse monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). 3. Immunochemical staining of human KI-67 in human esophageal carcinoma with mouse monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:500-1:2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with a synthetic peptide corresponding to the center region of the Human Ki67 / MKI67. The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | MKI67 contains 1 FHA domain and plays a key role in cell proliferation. During interphase, the MKI67 antigen can be exclusively detected within the cell nucleus, whereas in mitosis most of the protein is relocated to the surface of the chromosomes. MKI67 protein is present during all active phases of the cell cycle (G1, S, G2, and mitosis), but is absent from resting cells. MKI67 is an excellent marker to determine the growth fraction of a given cell population. The fraction of MKI67-positive tumor cells is often correlated with the clinical course of cancer. It is also associated with ribosomal RNA transcription. Inactivation of antigen MKI67 leads to inhibition of ribosomal RNA synthesis. The MKI67 protein is a nuclear and nucleolar protein, which is tightly associated with somatic cell proliferation. Antibodies raised against the human MKI67 protein paved the way for the immunohistological assessment of cell proliferation, particularly useful in numerous studies on the prognostic value of cell growth in clinical samples of human neoplasms. MKI67 protein expression is an absolute requirement for progression through the cell-division cycle. Recently, MKI67 is proved to be an independent prognostic factor for disease-free survival (HR 1.5-1.72) in multivariate analyses studies using samples from randomized clinical trials with secondary central analysis of the biomarker. MKI67 was not found to be predictive for long-term follow-up after chemotherapy. Nevertheless, high KI-67 was found to be associated with immediate pathological complete response in the neoadjuvant setting, with an LOE of II-B. MKI67 could be considered as a prognostic biomarker for therapeutic decision. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide corresponding to the center region of the Human Ki67 / MKI67 |
| 抗原种属 | Human |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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