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Anti-KEAP1 Antibody (8I308)

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货号 TMAB-07982

Anti-KEAP1 Antibody (8I308) 是一种 Rabbit 抗体，靶向 KEAP1。Anti-KEAP1 Antibody (8I308) 可用于 WB。

Anti-KEAP1 Antibody (8I308)

Anti-KEAP1 Antibody (8I308)

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Rating icon 还可以
货号 TMAB-07982

Anti-KEAP1 Antibody (8I308) 是一种 Rabbit 抗体，靶向 KEAP1。Anti-KEAP1 Antibody (8I308) 可用于 WB。

规格价格库存数量
25 μL
¥ 780
5日内发货
50 μL
¥ 1,380
5日内发货
100 μL
¥ 2,490
5日内发货
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产品介绍

生物活性
产品描述
Anti-KEAP1 Antibody (8I308) is a Rabbit antibody targeting KEAP1. Anti-KEAP1 Antibody (8I308) can be used in WB.
Ig Type
IgG
克隆号
8I308
反应种属
Human
验证活性
25 μg total protein per lane of various lysates (see on figure) probed with KEAP1 monoclonal antibody, unconjugated (TMAB-07982) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus.
组织特异性Broadly expressed, with highest levels in skeletal muscle.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008].
抗原信息
免疫原
KLH conjugated synthetic peptide: human KEAP1
抗原种属
Human
基因名称
KEAP1
基因ID
9817
蛋白名称
Kelch-like ECH-associated protein 1
Uniprot ID
Q14145
功能
Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
化学信息
分子量Theoretical: 69 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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