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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-KCC4 Polyclonal Antibody

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货号 TMAB-07921

Anti-KCC4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 KCC4。Anti-KCC4 Polyclonal Antibody 可用于 WB。

Anti-KCC4 Polyclonal Antibody

Anti-KCC4 Polyclonal Antibody

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货号 TMAB-07921

Anti-KCC4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 KCC4。Anti-KCC4 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-KCC4 Polyclonal Antibody is a Rabbit antibody targeting KCC4. Anti-KCC4 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse (predicted:Human,Rat,Pig,Horse)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Multi-pass membrane protein.
组织特异性Detected in muscle, brain, lung, heart and kidney.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.
抗原信息
免疫原
KLH conjugated synthetic peptide: human KCC4
抗原种属
Human
基因名称
SLC12A7
基因ID
10723
蛋白名称
Solute carrier family 12 member 7
Uniprot ID
Q9Y666
功能
Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification.
化学信息
分子量Theoretical: 119 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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