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Anti-JDP2 Polyclonal Antibody

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货号 TMAB-01007

别名 Progesterone receptor co-activator, JUNDM2, Jun dimerization protein 2, JDP 2

Anti-JDP2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 JDP2。Anti-JDP2 Polyclonal Antibody 可用于 WB。

Anti-JDP2 Polyclonal Antibody

Anti-JDP2 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-01007 别名 Progesterone receptor co-activator, JUNDM2, Jun dimerization protein 2, JDP 2

Anti-JDP2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 JDP2。Anti-JDP2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,785
5日内发货
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产品介绍

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产品描述
Anti-JDP2 Polyclonal Antibody is a Rabbit antibody targeting JDP2. Anti-JDP2 Polyclonal Antibody can be used in WB.
别名Progesterone receptor co-activator, JUNDM2, Jun dimerization protein 2, JDP 2
Ig Type
IgG
反应种属
Human,Mouse,Rat (predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit)
验证活性
Sample:
Lane 1: Mouse Testis tissue lysates
Lane 2: Rat Testis tissue lysates
Lane 3: Human HepG2 cell lysates
Lane 4: Human DU145 cell lysates
Lane 5: Human HeLa cell lysates
Primary: Anti-JDP2 (TMAB-01007) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 19 kDa
Observed band size: 22 kDa
verifiedActivity
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nucleus.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景c-Jun dimerization protein (JDP) 2 binds cAMP-response element (CRE) as a homodimer or as a heterodimer with ATF-2 and c-Jun. This dimerization allows JDP2 to repress CRE-dependent transcription. JDP2 is phosphorylated by c-Jun N-terminal kinase at Thr 138. JDP2 contains a basic leucine zipper (bZIP) region for DNA-binding. The bZIP region of JDP2 interacts with the DNA binding domain (DBD) of progesterone receptor (PR) in mammalian cells. Two other coactivators, creb binding protein (CBP) and p300 CBP-associated factor (PCAF), also associate with JDP2. Thus, JDP2 appears to stimulate the N-terminal activation function domain of PR by docking to the DBD and facilitation PR interaction with other coactivators. The expression of JDP2 in PR-targeted tissues and cells supports the role for JDP2 in PR function. In addition, JDP2 may play an important role in controlling the commitment of F9 embryonal carcinoma cells to differentiation. In undifferentiated F9 cells, JDP2 recruits HDAC3 and binds the differentiation response element within the c-jun promoter. Retinoic acid-induction replaces the JDP2/HDAC3 complex with PCAF and subsequently allows the transcription of c-Jun for F9 differentiation. The gene encoding human JDP2 maps to chromosome 14q24.2.
抗原信息
免疫原
KLH conjugated synthetic peptide: human JDP2
抗原种属
Human
基因名称
JDP2
基因ID
122953
蛋白名称
Jun dimerization protein 2
Uniprot ID
Q8WYK2
研究领域
Leucine Zipper
功能
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
化学信息
分子量Theoretical: 19 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

  • 稀释 计算器
  • 配液 计算器
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