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Anti-JAK3 Antibody (8C887)
还可以产品编号 TMAH-00656
别名 Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (8C887) 是一种抗体，靶向 JAK3。Anti-JAK3 Antibody (8C887) 可用于 ELISA, IHC。
Anti-JAK3 Antibody (8C887)
Anti-JAK3 Antibody (8C887)
还可以产品编号 TMAH-00656 别名 Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (8C887) 是一种抗体，靶向 JAK3。Anti-JAK3 Antibody (8C887) 可用于 ELISA, IHC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,305 | 5日内发货 | |
| 100 μL | ¥ 2,185 | 5日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-JAK3 Antibody (8C887) is an antibody targeting JAK3. Anti-JAK3 Antibody (8C887) can be used in ELISA, IHC. |
| 别名 | Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2 |
| Ig Type | Rabbit IgG |
| 克隆号 | 8C887 |
| 交叉反应 | Human |
| 验证活性 | IHC image of TMAH-00656 diluted at 1:100 and staining in paraffin-embedded human lung cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| 应用 | ELISA, IHC |
| 推荐剂量 | IHC:1:50-1:200. |
| 抗体种类 | Monoclonal |
| 亚细胞定位 | Endomembrane system; Peripheral membrane protein. Cytoplasm. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Affinity-chromatography |
| 性状 | Liquid |
| 缓冲液 | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 研究背景 | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. Once activated, dimerized STAT5 translocates to the nucleus and promotes the transcription of specific target genes in a cytokine-specific fashion. |
| 偶联 | Unconjugated |
| 免疫原 | A synthetic peptide: Human JAK3 |
| 抗原种属 | Human |
| 基因ID | 3718 |
| Uniprot ID | |
| 研究领域 | Epigenetics and Nuclear Signaling, Cancer, Signal transduction |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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