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Anti-JAK3 Antibody (5S507)
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产品编号 TMAC-02278
别名 Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (5S507) 是一种 Rabbit 抗体，靶向 JAK3。Anti-JAK3 Antibody (5S507) 可用于 WB,IHC,ICC。
Anti-JAK3 Antibody (5S507)
Anti-JAK3 Antibody (5S507)
还可以产品编号 TMAC-02278 别名 Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2
Anti-JAK3 Antibody (5S507) 是一种 Rabbit 抗体，靶向 JAK3。Anti-JAK3 Antibody (5S507) 可用于 WB,IHC,ICC。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 50 μL | ¥ 1,485 | 5日内发货 | |
| 100 μL | ¥ 2,490 | 5日内发货 |
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抗原信息
化学信息
| 产品描述 | Anti-JAK3 Antibody (5S507) is a Rabbit antibody targeting JAK3. Anti-JAK3 Antibody (5S507) can be used in WB,IHC,ICC. |
| 别名 | Tyrosine-protein kinase JAK3, L-JAK, Leukocyte janus kinase, Janus kinase 3, JAK-3, EC 2.7.10.2 |
| Ig Type | IgG |
| 克隆号 | 5S507 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunohistochemical analysis of paraffin-embedded human spleen tissue using anti-JAK3 antibody. Counter stained with hematoxylin. 2. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-JAK3 antibody. Counter stained with hematoxylin. 3. ICC staining JAK3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. |
| 应用 | |
| 推荐剂量 | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:50-100 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | ProA affinity purified |
| 性状 | Liquid |
| 缓冲液 | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| 研究背景 | Non-receptor tyrosine kinase involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, upon IL2R activation by IL2, JAK1 and JAK3 molecules bind to IL2R beta (IL2RB) and gamma chain (IL2RG) subunits inducing the tyrosine phosphorylation of both receptor subunits on their cytoplasmic domain. Then, STAT5A AND STAT5B are recruited, phosphorylated and activated by JAK1 and JAK3. |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Protein |
| Uniprot ID |
| 分子量 | Theoretical: 125 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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