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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-ITM2B Polyclonal Antibody

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货号 TMAB-07840

Anti-ITM2B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ITM2B。Anti-ITM2B Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-ITM2B Polyclonal Antibody

Anti-ITM2B Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07840

Anti-ITM2B Polyclonal Antibody 是一种 Rabbit 抗体，靶向 ITM2B。Anti-ITM2B Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-ITM2B Polyclonal Antibody is a Rabbit antibody targeting ITM2B. Anti-ITM2B Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Golgi apparatus membrane. Cell membrane.
组织特异性Expressed in brain and in other tissues.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The type II integral membrane (ITM2) protein family consists of three members: ITM2A (also designated E25), ITM2B and ITM2C. ITM2A expression is high in osteogenic and lymphoid tissues, while both ITM2B and ITM2C are expressed in brain. ITM2B is a 266 amino acid protein that contains a potential N-glycosylation site, a potential single transmembrane-spanning domain between amino acids 52 and 74 and an extracellular C-terminal domain. Mutations in the ITM2B gene can lead to familial British dementia (FBD), and autosomal dominant disease with an onset around the fifth decade of life that is characterized by progressive dementia, spasticity and cerebellar ataxia. Familial Danish dementia (FDD), also designated heredopathia ophthalmo-oto-encephalica, is also associated with mutations in the ITM2B gene. FDD is an autosomal dominant disorder characterized by cataracts, deafness, progressive ataxia and dementia.
抗原信息
免疫原
KLH conjugated synthetic peptide: human ITM2B
抗原种属
Human
基因名称
ITM2B
基因ID
9445
蛋白名称
Integral membrane protein 2B
Uniprot ID
Q9Y287
功能
Functions as a protease inhibitor. Plays a role in APP processing regulating the physiological production of the beta amyloid peptide. Restricts docking of gamma-secretase to APP and access of alpha- and beta-secretase to their cleavage APP sequence.
化学信息
分子量Theoretical: 30 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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