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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-IREB2 Polyclonal Antibody

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货号 TMAB-00984

别名 OTTHUMP00000185022, IRP2AD, IRP-2, irp2, IRP2, Iron-responsive element-binding protein 2, iron regulatory protein 2, IRE-BP 2, IREB2, IREB 2, IRE BP2, FLJ23381, ACO3

Anti-IREB2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IREB2。Anti-IREB2 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

Anti-IREB2 Polyclonal Antibody

Anti-IREB2 Polyclonal Antibody

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货号 TMAB-00984 别名 OTTHUMP00000185022, IRP2AD, IRP-2, irp2, IRP2, Iron-responsive element-binding protein 2, iron regulatory protein 2, IRE-BP 2, IREB2, IREB 2, IRE BP2, FLJ23381, ACO3

Anti-IREB2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IREB2。Anti-IREB2 Polyclonal Antibody 可用于 IF,IHC-Fr,IHC-P。

规格价格库存数量
50 μL
¥ 1,160
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-IREB2 Polyclonal Antibody is a Rabbit antibody targeting IREB2. Anti-IREB2 Polyclonal Antibody can be used in IF,IHC-Fr,IHC-P.
别名OTTHUMP00000185022, IRP2AD, IRP-2, irp2, IRP2, Iron-responsive element-binding protein 2, iron regulatory protein 2, IRE-BP 2, IREB2, IREB 2, IRE BP2, FLJ23381, ACO3
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat,Chicken,Dog,Rabbit)
验证活性
1. Paraformaldehyde-fixed, paraffin embedded (human kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (IREB2) Polyclonal Antibody, Unconjugated (TMAB-00984) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
2. Paraformaldehyde-fixed, paraffin embedded (Human duodenum); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (IREB2) Polyclonal Antibody, Unconjugated (TMAB-00984) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
3. Paraformaldehyde-fixed, paraffin embedded (mouse kidney); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 min; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (IREB2) Polyclonal Antibody, Unconjugated (TMAB-00984) at 1:200 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructionsand DAB staining.
verifiedActivityverifiedActivityverifiedActivity
应用IFIHC-FrIHC-P
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景Iron metabolism is essential for sustaining mammalian homeostasis. Iron uptake and distribution is a highly regulated process in mammalian cells that is monitored by two iron sensing proteins: IRP-1 and -2 (iron regulatory protein-1 and -2), also known as iron responsive element-binding protein-1 and -2 (IRE-BP-1 and -2) or aconitase 1 and 2. IRP-1 and IRP-2 are important soluble regulatory factors that mediate iron uptake and storage in mammalian cells. They are capable of either repressing translation or enhancing mRNA stability by associating with stem-loop motifs known as iron-responsive elements (IREs). IRPs respond to stress mediators, iron concentration and signaling factors, including nitrogen monoxide, cytokines and hydrogen peroxide.
抗原信息
免疫原
KLH conjugated synthetic peptide: human IREB2
抗原种属
Human
基因名称
IREB2
基因ID
3658
蛋白名称
Iron-responsive element-binding protein 2
Uniprot ID
P48200
研究领域
Blood,Hypoxia-Regulated,RNA Processing,Vitamins / minerals,Energy Metabolism,Nucleotide metabolism,Hypoxia,Energy Metabolism,Vitamins / Minerals
功能
RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
化学信息
分子量Theoretical: 105 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

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