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Anti-Insulin Receptor Antibody (1Q226)
还可以产品编号 TMAY-01627
Anti-Insulin Receptor Antibody (1Q226) 是一种 Mouse 抗体，靶向 Insulin Receptor。Anti-Insulin Receptor Antibody (1Q226) 可用于 IHC-P。
Anti-Insulin Receptor Antibody (1Q226)
Anti-Insulin Receptor Antibody (1Q226)
还可以产品编号 TMAY-01627
Anti-Insulin Receptor Antibody (1Q226) 是一种 Mouse 抗体，靶向 Insulin Receptor。Anti-Insulin Receptor Antibody (1Q226) 可用于 IHC-P。
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抗原信息
| 产品描述 | Anti-Insulin Receptor Antibody (1Q226) is a Mouse antibody targeting Insulin Receptor. Anti-Insulin Receptor Antibody (1Q226) can be used in IHC-P. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 1Q226 |
| 交叉反应 | Human |
| 验证活性 | 1. Immunochemical staining of human INSR in human placenta with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). 2. Immunochemical staining of human INSR in human kidney with mouse monoclonal antibody (1:200, formalin-fixed paraffin embedded sections). |
| 应用 | IHC-P |
| 推荐剂量 | IHC-P: 1:100-1:500 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human Insulin Receptor/INSR/CD220 (rh Insulin Receptor/INSR/CD220; TMPY-01149; NP_001073285.1; Met1-Lys944). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | 0.2 μm filtered solution in PBS |
| 研究背景 | INSR (Insulin receptor), also known as CD220, is a transmembrane receptor that is activated by insulin. INSR belongs to the protein kinase superfamily and exists as a tetramer consisting of two alpha subunits and two beta subunits linked by disulfide bonds. The alpha and beta subunits are encoded by a single INSR gene, and the beta subunits pass through the cellular membrane. As the receptor for insulin with tyrosine-protein kinase activity, INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3'-kinase (PI3K). IRS-1 binding and phosphorylation eventually lead to an increase in the high-affinity glucose transporter (Glut4) molecules on the outer membrane of insulin-responsive tissues. INSR isoform long and isoform short are expressed in the peripheral nerve, kidney, liver, striated muscle, fibroblasts and skin, and is found as a hybrid receptor with IGF1R which also binds IGF1 in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen, and placenta. Defects in Insulin Receptor/INSR are the cause of Rabson-Mendenhall syndrome (Mendenhall syndrome), insulin resistance (Ins resistance), leprechaunism (Donohue syndrome), and familial hyperinsulinemic hypoglycemia 5 (HHF5). It may also be associated with noninsulin-dependent diabetes mellitus (NIDDM). |
| 偶联 | Unconjugated |
| 免疫原 | Recombinant Human Insulin Receptor/INSR/CD220 Protein (TMPY-01149) |
| 抗原种属 | Human |
| 研究领域 | Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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