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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-IL23 P19 Polyclonal Antibody

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货号 TMAB-07639

Anti-IL23 P19 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IL23 P19。Anti-IL23 P19 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-IL23 P19 Polyclonal Antibody

Anti-IL23 P19 Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07639

Anti-IL23 P19 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IL23 P19。Anti-IL23 P19 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,170
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100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-IL23 P19 Polyclonal Antibody is a Rabbit antibody targeting IL23 P19. Anti-IL23 P19 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Dog,Pig,Cow,Horse,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted. Secreted upon association with IL12B.
组织特异性Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景IL-23 is a heterodimeric cytokine composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T cells and promotes production of proinflammatory cytokines, such as IFNγ and IL-17. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. This recombinant human IL-23 is produced by human cells.(Tag free) Biological activity: The activity was measured by its ability to induce the IL-17 expression in murine splenocytes. Reconstitution: Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
抗原信息
免疫原
KLH conjugated synthetic peptide: human IL23 P19
抗原种属
Human
基因名称
Il23a
基因ID
51561
蛋白名称
Interleukin-23 subunit alpha
Uniprot ID
Q9NPF7
功能
Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
化学信息
分子量Theoretical: 19 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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