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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-IL-17A Polyclonal Antibody

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货号 TMAB-00945

别名 interleukin 17A, IL-17CTLA-8, IL17A, IL17, CTLA-8

Anti-IL-17A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IL-17A。Anti-IL-17A Polyclonal Antibody 可用于 IF,IHC-Fr,WB。

Anti-IL-17A Polyclonal Antibody

Anti-IL-17A Polyclonal Antibody

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货号 TMAB-00945 别名 interleukin 17A, IL-17CTLA-8, IL17A, IL17, CTLA-8

Anti-IL-17A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IL-17A。Anti-IL-17A Polyclonal Antibody 可用于 IF,IHC-Fr,WB。

规格价格库存数量
50 μL
¥ 1,170
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-IL-17A Polyclonal Antibody is a Rabbit antibody targeting IL-17A. Anti-IL-17A Polyclonal Antibody can be used in IF,IHC-Fr,WB.
别名interleukin 17A, IL-17CTLA-8, IL17A, IL17, CTLA-8
Ig Type
IgG
反应种属
Mouse,Rat
验证活性
Sample:
Lane 1: Rat LympHnode tissue lysates
Lane 2: Mouse LympHnode tissue lysates
Lane 3: Rat Thymus tissue lysates
Primary: Anti-IL17A (TMAB-00945) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 15 kDa
Observed band size: 22 kDa
verifiedActivity
应用IFIHC-FrWB
推荐剂量
WB: 1:500-2000; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Secreted.
组织特异性Restricted to a subset of activated T-cells.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1 mg/mL
研究背景This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]
抗原信息
免疫原
KLH conjugated synthetic peptide: mouse IL-17
抗原种属
Mouse
基因名称
IL17A
基因ID
16171
蛋白名称
Interleukin-17A
Uniprot ID
Q62386
研究领域
Interleukins,Interleukins
功能
Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts.
化学信息
分子量Theoretical: 15 kDa. Actual: 15-17 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | store at -20°C

计算器

  • 稀释 计算器

关键词

IL-17IL 17CTLA8CTLA 8
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