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Anti-IKZF1 Monoclonal Antibody (5F492)

Synonyms: ZNFN1A1, PRO0758, PPP1R92, LyF-1, LYF1, IKAROS, IK1, Hs.54452, CVID13
货号 TMAT-1275 一键复制产品信息
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Anti-IKZF1 Monoclonal Antibody (5F492) 是一种 Mouse 抗体，靶向 IKZF1。Anti-IKZF1 Monoclonal Antibody (5F492) 可用于 IF,FCM。

Anti-IKZF1 Monoclonal Antibody (5F492)

一键复制产品信息
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货号 TMAT-1275

别名 ZNFN1A1, PRO0758, PPP1R92, LyF-1, LYF1, IKAROS, IK1, Hs.54452, CVID13

Anti-IKZF1 Monoclonal Antibody (5F492) 是一种 Mouse 抗体，靶向 IKZF1。Anti-IKZF1 Monoclonal Antibody (5F492) 可用于 IF,FCM。

Anti-IKZF1 Monoclonal Antibody (5F492)
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产品介绍

生物活性
产品描述
Anti-IKZF1 Monoclonal Antibody (5F492) is a Mouse antibody targeting IKZF1. Anti-IKZF1 Monoclonal Antibody (5F492) can be used in IF,FCM.
别名
ZNFN1A1, PRO0758, PPP1R92, LyF-1, LYF1, IKAROS, IK1, Hs.54452, CVID13
Ig Type
IgG2b
克隆号
5F492
反应种属
Human
应用IFFCM
推荐剂量
IF: 1/200-1/1000; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/mL
研究背景This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human IKZF1 (AA: 401-520) expressed in E. Coli.
抗原种属
Human
基因名称
IKZF1
基因ID
10320
蛋白名称
DNA-binding protein Ikaros
Uniprot ID
Q13422
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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