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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-IKIP Polyclonal Antibody

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货号 TMAB-07576

Anti-IKIP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IKIP。Anti-IKIP Polyclonal Antibody 可用于 WB。

Anti-IKIP Polyclonal Antibody

Anti-IKIP Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07576

Anti-IKIP Polyclonal Antibody 是一种 Rabbit 抗体，靶向 IKIP。Anti-IKIP Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-IKIP Polyclonal Antibody is a Rabbit antibody targeting IKIP. Anti-IKIP Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Mouse,Rat (predicted:Human,Cow,Horse,Sheep)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Endoplasmic reticulum membrane; Single-pass membrane protein. Note=Isoform 4 deletion of the hydrophobic, or transmembrane region between AA 45-63 results in uniform distribution throughout the cell, suggesting that this region is responsible for endoplasmic reticulum localization.
组织特异性Expressed in vein endothelial cells. Isoform 4 is expressed in lung, kidney, spleen, thymus and skeletal muscle.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景IKIP (I kappa B kinase interacting protein)is located on chromosome 12 in close proximity to APAF1 (apoptotic protease-activating factor-1). IKIP was originally cloned from a yeast two hybrid screening as an IKK2 interacting protein. IKIP and APAF1 share a common 488 bp promoter from which the two genes are transcribed in opposite directions, presumably in a co-regulated manner. Three IKIP transcripts are generated by differential splicing and alternative exon usage and show no significant homology to other genes. IKIP is expressed predominantly in the lung, kidney, spleen, thymus and skeletal muscle. Like APAF1, expression of IKIP is enhanced by irradiation, in a p53-dependent manner. When transfected into endothelial cells IKIP promotes apoptosis suggesting that it plays a role in the cell death process as well as NF-kB regulation.
抗原信息
免疫原
KLH conjugated synthetic peptide: human IKIP
抗原种属
Human
基因名称
IKBIP
基因ID
121457
蛋白名称
Inhibitor of nuclear factor kappa-B kinase-interacting protein
功能
Target of p53/TP53 with pro-apoptotic function.
化学信息
分子量Theoretical: 39 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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