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Anti-HVEM Antibody (8R903)

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Anti-HVEM Antibody (8R903)
产品编号 TMAY-00635
别名 tumor necrosis factor receptor superfamily, member 14, TR2, LIGHTR, HVEM, HVEA, CD270, ATAR

Anti-HVEM Antibody (8R903) 是一种 Rabbit 抗体，靶向 HVEM。Anti-HVEM Antibody (8R903) 可用于 FCM。

Anti-HVEM Antibody (8R903)
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Anti-HVEM Antibody (8R903)

Rating icon 还可以
Anti-HVEM Antibody (8R903)
产品编号 TMAY-00635 别名 tumor necrosis factor receptor superfamily, member 14, TR2, LIGHTR, HVEM, HVEA, CD270, ATAR

Anti-HVEM Antibody (8R903) 是一种 Rabbit 抗体，靶向 HVEM。Anti-HVEM Antibody (8R903) 可用于 FCM。

规格价格库存数量
100 μL
¥ 2,289
5日内发货
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产品介绍

生物活性
产品描述
Anti-HVEM Antibody (8R903) is a Rabbit antibody targeting HVEM. Anti-HVEM Antibody (8R903) can be used in FCM.
别名tumor necrosis factor receptor superfamily, member 14, TR2, LIGHTR, HVEM, HVEA, CD270, ATAR
Ig Type
Rabbit IgG
克隆号
8R903
交叉反应
Human
验证活性
Flow cytometric analysis of Human HVEM(CD270) expression on human whole blood lymphocytes. Cells were stained with purified anti-Mouse Human HVEM(CD270), then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
应用
FCM
推荐剂量
FCM: 1:25-1:100
抗体种类
Monoclonal
宿主来源Rabbit
构建方式This antibody was obtained from a rabbit immunized with purified, recombinant Human HVEM/TNFRSF14/CD270 (rh HVEM/TNFRSF14/CD270; TMPY-01750; NP_003811.2; Met1-Val202).
纯化方式Protein A
性状Liquid
缓冲液0.2 μm filtered solution in PBS
研究背景Herpesvirus entry mediator (HVEM), also referred to as TNFRSF14, TR2 (TNF receptor-like molecule) and ATAR (another TRAF-associated receptor), is a member of type I transmembrane protein belonging to the TNF-receptor superfamily. It is expressed on many immune cells, including T and B cells, NK cells, monocytes, and neutrophils. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling. However, recent studies have revealed that HVEM is also involved in the unique inhibitory signaling pathway for T cells through activating tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in B and T lymphocyte attenuator (BTLA). HVEM provides a stimulatory signal following engagement with LIGHT (TNFSF14) on T cells. In contrast, it can also provide an inhibitory signal to T cells when it binds the B and T lymphocyte attenuator (BTLA), a ligand member of the Immunoglobulin (Ig) superfamily. Thus, HVEM may be viewed as a molecular switch, capable of facilitating both stimulatory and inhibitory cosignaling in T cells. Substantial evidence from both human disease and from experimental mouse models has indicated that dysregulation of the LIGHT-HVEM-BTLA cosignaling pathway can cause inflammation in the lung and in mucosal tissues.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy
偶联与修饰
偶联
Unconjugated
其他可选修饰符
APC/FITC/PE
可提供抗体种类
4
抗原信息
免疫原
Recombinant Protein: Human HVEM/TNFRSF14/CD270 Protein (TMPY-01750)
抗原种属
Human
研究领域
Cancer Drug Targets
存储&运输
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
运输方式Shipping with blue ice.

计算器

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关键词

TR-2TR 2CD-270CD 270

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4个月前
5.0
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