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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-Human IgD Antibody (8T259)

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货号 TMAB-07437

Anti-Human IgD Antibody (8T259) 是一种 Rabbit 抗体，靶向 Human IgD。Anti-Human IgD Antibody (8T259) 可用于 IHC-P,IHC-Fr,IF。

Anti-Human IgD Antibody (8T259)

Anti-Human IgD Antibody (8T259)

一键复制产品信息
Rating icon 还可以
货号 TMAB-07437

Anti-Human IgD Antibody (8T259) 是一种 Rabbit 抗体，靶向 Human IgD。Anti-Human IgD Antibody (8T259) 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
25 μL
¥ 790
5日内发货
50 μL
¥ 1,385
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

生物活性
产品描述
Anti-Human IgD Antibody (8T259) is a Rabbit antibody targeting Human IgD. Anti-Human IgD Antibody (8T259) can be used in IHC-P,IHC-Fr,IF.
克隆号
8T259
反应种属
Human
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:50-200; IHC-Fr: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Isoform 1: Secreted.Isoform 2: Cell membrane; Single-pass type I membrane protein.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Ig delta chain C region is an allelic product of the human IGHD gene. The two known IGHD alleles, IGHD*01 and IGHD*02, respectively produce isoforms 1, a secreted protein, and 2, a single-pass type I membrane protein. A member of the adaptive immune system, IgD antibodies are monomers expressed by activated B cells. Containing 3 Ig-like (immunoglobulin-like) domains, IgD chain C is located on chromosome 14 within the human heavy chain locus, lying on the 3’ side of the IgM chain C region from the V-D-J cassette. Polyadenylation at certain sites along the heavy chain locus likely effects the mechanism that determines the alternative splicing event which results in the expression of either IgD chain C or IgM chain C. Some studies have suggested that antigenic coactivation of IgD+ B cells can have a negative influence on bone resorption during infectious events.
抗原信息
基因名称
IGHD
基因ID
3495
蛋白名称
Immunoglobulin heavy constant delta
功能
IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.
化学信息
分子量Theoretical: 42 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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