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顶部产品介绍偶联与修饰抗原信息化学信息储存和溶解信息计算器

Anti-HSPA5 Monoclonal Antibody (4C794)

Synonyms: MIF2, HSPA5, GRP78, FLJ26106, BIP
货号 TMAT-0803 一键复制产品信息
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Anti-HSPA5 Monoclonal Antibody (4C794) 是一种 Mouse 抗体，靶向 HSPA5。Anti-HSPA5 Monoclonal Antibody (4C794) 可用于 WB,IHC,IF,FCM。

Anti-HSPA5 Monoclonal Antibody (4C794)

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Rating icon 还可以
货号 TMAT-0803

别名 MIF2, HSPA5, GRP78, FLJ26106, BIP

Anti-HSPA5 Monoclonal Antibody (4C794) 是一种 Mouse 抗体，靶向 HSPA5。Anti-HSPA5 Monoclonal Antibody (4C794) 可用于 WB,IHC,IF,FCM。

Anti-HSPA5 Monoclonal Antibody (4C794)
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产品介绍

生物活性
产品描述
Anti-HSPA5 Monoclonal Antibody (4C794) is a Mouse antibody targeting HSPA5. Anti-HSPA5 Monoclonal Antibody (4C794) can be used in WB,IHC,IF,FCM.
别名
MIF2, HSPA5, GRP78, FLJ26106, BIP
Ig Type
IgG1
克隆号
4C794
反应种属
Human,Mouse,Rat,Monkey,Rabbit
应用WBIHCIFFCM
推荐剂量
WB: 1/500-1/2000; IHC: 1/100-1/500; IF: 1/50-1/500; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide.
浓度1 mg/mL
研究背景When Chinese hamster K12 cells are starved of glucose, the synthesis of several proteins, called glucose-regulated proteins (GRPs), is markedly increased. Hendershot et al. (1994) (PubMed 8020977) pointed out that one of these, GRP78 (HSPA5), also referred to as 'immunoglobulin heavy chain-binding protein' (BiP), is a member of the heat-shock protein-70 (HSP70) family and is involved in the folding and assembly of proteins in the endoplasmic reticulum (ER). Because so many ER proteins interact transiently with GRP78, it may play a key role in monitoring protein transport through the cell.Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.The HSP70 proteins are ubiquitous molecular chaparones that are found in all organisms and tissue types. Like other members of the HSP70 family, BiP is a peptide-binding ATPase that is able to differentiate native proteins from unfolded polypeptides. BiP does not bind to fully folded and assembled proteins, except in the presence of other co-chaparones. BiP is involved in a number of key mechanisms and pathways including polypeptide translocation across the endoplasmic reticulum, folding, assembly, transport of secreted or membrane proteins, and the regulation of calcium homeostasis. Although BiP is relatively abundant, marked increases in BiP occur where there is an accumulation of unfolded polypeptides. For this reason, BiP has been identified as a marker for various disease states that are associated with secretory and transmembrane protein misfolding.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human HSPA5 expressed in E. Coli.
抗原种属
Human
基因名称
HSPA5
基因ID
3309
蛋白名称
Endoplasmic reticulum chaperone BiP
Uniprot ID
P11021
化学信息
分子量Theoretical: 78 kDa.
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

计算器

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