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Anti-HMGCR Antibody (7G912)
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还可以产品编号 TMAB-00873
别名 HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Anti-HMGCR Antibody (7G912) 是一种 Rabbit 抗体，靶向 HMGCR。Anti-HMGCR Antibody (7G912) 可用于 WB。
Anti-HMGCR Antibody (7G912)
Anti-HMGCR Antibody (7G912)
一键复制产品信息 还可以产品编号 TMAB-00873 别名 HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Anti-HMGCR Antibody (7G912) 是一种 Rabbit 抗体，靶向 HMGCR。Anti-HMGCR Antibody (7G912) 可用于 WB。
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μL | ¥ 795 | 5日内发货 | |
| 50 μL | ¥ 1,385 | 5日内发货 | |
| 100 μL | ¥ 2,480 | 5日内发货 |
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| 产品描述 | Anti-HMGCR Antibody (7G912) is a Rabbit antibody targeting HMGCR. Anti-HMGCR Antibody (7G912) can be used in WB. |
| 别名 | HMGCR, HMG-CoA reductase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Ig Type | IgG |
| 克隆号 | 7G912 |
| 交叉反应 | Human |
| 验证活性 | 25 μg total protein per Lane of various lysates probed with HMGCR monoclonal antibody, unconjugated (TMAB-00873) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at RT for 60 min.  |
| 应用 | WB |
| 推荐剂量 | WB: 1:500-2000 |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Endoplasmic reticulum membrane. Peroxisome membrane. |
| 构建方式 | Recombinant Antibody |
| 纯化方式 | Protein A purified |
| 性状 | Liquid |
| 缓冲液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 浓度 | 1 mg/mL |
| 研究背景 | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. |
| 免疫原 | A synthesized peptide: human HMGCR |
| 抗原种属 | Human |
| 基因名称 | HMGCR |
| 基因ID | |
| 蛋白名称 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Uniprot ID | |
| 研究领域 | Metabolism of lipids and lipoproteins,Lipoprotein metabolism,Cholesterol Metabolism,Cholesterol Metabolism,Lipid metabolism,Lipoprotein metabolism,Heart disease,Lipid metabolism |
| 功能 | This transmembrane glycoprotein is involved in the control of cholesterol biosynthesis. It is the rate-limiting enzyme of sterol biosynthesis. |
| 分子量 | Theoretical: 97 kDa. |
存储&运输
| 储存方式 | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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