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Anti-HLADQA1+HLADQA2 Polyclonal Antibody

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货号 TMAB-07164

Anti-HLADQA1+HLADQA2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HLADQA1+HLADQA2。Anti-HLADQA1+HLADQA2 Polyclonal Antibody 可用于 WB。

Anti-HLADQA1+HLADQA2 Polyclonal Antibody

Anti-HLADQA1+HLADQA2 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-07164

Anti-HLADQA1+HLADQA2 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HLADQA1+HLADQA2。Anti-HLADQA1+HLADQA2 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,175
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100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-HLADQA1+HLADQA2 Polyclonal Antibody is a Rabbit antibody targeting HLADQA1+HLADQA2. Anti-HLADQA1+HLADQA2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Chimpanzee, Cynomolgus Monkey)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus > trans-Golgi network membrane. Endosome membrane. Lysosome membrane. The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
组织特异性Expressed at low levels at the surface of B lymphoblastoid cells.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form an heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal miroenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
抗原信息
免疫原
KLH conjugated synthetic peptide: human HLADQA1 + HLADQA2
抗原种属
Human
基因名称
HLA-DQA2
基因ID
100133678
蛋白名称
HLA class II histocompatibility antigen, DQ alpha 2 chain
Uniprot ID
P01909
功能
HLADQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). HLADQA2 forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site.
化学信息
分子量Theoretical: 26 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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