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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HLA Class II DR4 Polyclonal Antibody

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货号 TMAB-07149

Anti-HLA Class II DR4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HLA Class II DR4。Anti-HLA Class II DR4 Polyclonal Antibody 可用于 WB。

Anti-HLA Class II DR4 Polyclonal Antibody

Anti-HLA Class II DR4 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-07149

Anti-HLA Class II DR4 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HLA Class II DR4。Anti-HLA Class II DR4 Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-HLA Class II DR4 Polyclonal Antibody is a Rabbit antibody targeting HLA Class II DR4. Anti-HLA Class II DR4 Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human (predicted:Monkey)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cell membrane 3 Publications; Single-pass type I membrane protein. Endoplasmic reticulum membrane 1 Publication; Single-pass type I membrane protein. Lysosome membrane 2 Publications; Single-pass type I membrane protein. Late endosome membrane 2 Publications; Single-pass type I membrane protein. Autolysosome membrane.
组织特异性Expressed in professional APCs: monocyte/macrophages, dendritic cells and B cells (at protein level)Expressed in thymic epithelial cells (at protein level)
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]
抗原信息
免疫原
KLH conjugated synthetic peptide: human HLA Class II DR4
抗原种属
Human
基因名称
HLA-DRB1
基因ID
3123
蛋白名称
HLA class II histocompatibility antigen, DRB1 beta chain
功能
A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells
化学信息
分子量Theoretical: 26 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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