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顶部产品介绍偶联与修饰抗原信息储存和溶解信息计算器

Anti-HLA-C Monoclonal Antibody (1M284)

Synonyms: PSORS1, MHC, HLC-C, HLA-JY3, HLAC, D6S204
货号 TMAT-0794 一键复制产品信息
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Anti-HLA-C Monoclonal Antibody (1M284) 是一种 Mouse 抗体，靶向 HLA-C。Anti-HLA-C Monoclonal Antibody (1M284) 可用于 IHC,IF,FCM。

Anti-HLA-C Monoclonal Antibody (1M284)

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Rating icon 还可以
货号 TMAT-0794

别名 PSORS1, MHC, HLC-C, HLA-JY3, HLAC, D6S204

Anti-HLA-C Monoclonal Antibody (1M284) 是一种 Mouse 抗体，靶向 HLA-C。Anti-HLA-C Monoclonal Antibody (1M284) 可用于 IHC,IF,FCM。

Anti-HLA-C Monoclonal Antibody (1M284)
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产品介绍

生物活性
产品描述
Anti-HLA-C Monoclonal Antibody (1M284) is a Mouse antibody targeting HLA-C. Anti-HLA-C Monoclonal Antibody (1M284) can be used in IHC,IF,FCM.
别名
PSORS1, MHC, HLC-C, HLA-JY3, HLAC, D6S204
Ig Type
IgG1
克隆号
1M284
反应种属
Human
应用IHCIFFCM
推荐剂量
IHC: 1/200-1/1000; IF: 1/50-1/200; FCM: 1/200-1/400
抗体种类
Monoclonal
宿主来源Mouse
构建方式Hybridoma Monoclonal Antibody
纯化方式Purified by protein A or protein G
性状Liquid
缓冲液PBS with 0.05% sodium azide
浓度1 mg/mL
研究背景HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.
偶联与修饰
偶联
Unconjugated
抗原信息
免疫原
Purified recombinant fragment of human HLA-C (AA: 25-308) expressed in E. Coli.
抗原种属
Human
基因名称
HLA-C
基因ID
3107
蛋白名称
HLA class I histocompatibility antigen, C alpha chain
Uniprot ID
P10321
储存&溶解度
储存方式Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.

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