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Anti-HLA-C Antibody (3Y828)

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货号 TMAB-07159

Anti-HLA-C Antibody (3Y828) 是一种 Mouse 抗体，靶向 HLA-C。Anti-HLA-C Antibody (3Y828) 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

Anti-HLA-C Antibody (3Y828)

Anti-HLA-C Antibody (3Y828)

一键复制产品信息
Rating icon 还可以
货号 TMAB-07159

Anti-HLA-C Antibody (3Y828) 是一种 Mouse 抗体，靶向 HLA-C。Anti-HLA-C Antibody (3Y828) 可用于 WB,IHC-P,IHC-Fr,IF,FCM。

规格价格库存数量
200 μg
¥ 5,585
5日内发货
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,975
5日内发货
200 μL
¥ 2,790
5日内发货
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产品介绍

生物活性
产品描述
Anti-HLA-C Antibody (3Y828) is a Mouse antibody targeting HLA-C. Anti-HLA-C Antibody (3Y828) can be used in WB,IHC-P,IHC-Fr,IF,FCM.
Ig Type
IgG
克隆号
3Y828
反应种属
Human
应用WBIHC-PIHC-FrIFFCM
推荐剂量
WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:400-800; IF: 1:100-500; FCM: 1μg/Test
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Cell Membrane; Type I membrane protein.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. About 6000 HLA-C alleles have been described. The HLA system plays an important role in the occurrence and outcome of infectious diseases, including those caused by the malaria parasite, the human immunodeficiency virus (HIV), and the severe acute respiratory syndrome coronavirus (SARS-CoV). The structural spike and the nucleocapsid proteins of the novel coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19), are reported to contain multiple Class I epitopes with predicted HLA restrictions. Individual HLA genetic variation may help explain different immune responses to a virus across a population.[provided by RefSeq, Aug 2020]
抗原信息
免疫原
Recombinant Protein: human HLA-C protein
抗原种属
Human
基因名称
HLA-C
基因ID
3107
蛋白名称
HLA class I histocompatibility antigen, C alpha chain
Uniprot ID
P10321
功能
HLA-C (Major Histocompatibility Complex, Class I, C) is a Protein Coding gene. Diseases associated with HLA-C include Psoriasis 1 and Human Immunodeficiency Virus Type 1. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Interferon gamma signaling. Gene Ontology (GO) annotations related to this gene include signaling receptor binding and TAP binding. An important paralog of this gene is HLA-B.
化学信息
分子量Theoretical: 4 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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