Anti-Histone H3.3 Antibody (3Z104) is a Rabbit antibody targeting Histone H3.3. Anti-Histone H3.3 Antibody (3Z104) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,ELISA.

IgG

3Z104

Human

WB: 1:200-1000; IHC-P: 1:100-400; IHC-Fr: 1:100-400; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000

Monoclonal

Recombinant Protein: human Histone H3.3 protein, full length

Human

H3-3A

Histone H3.3

Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.