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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HIF1AN Antibody (8C810)

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货号 TMAB-07032

Anti-HIF1AN Antibody (8C810) 是一种 Rabbit 抗体，靶向 HIF1AN。Anti-HIF1AN Antibody (8C810) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

Anti-HIF1AN Antibody (8C810)

Anti-HIF1AN Antibody (8C810)

一键复制产品信息
Rating icon 还可以
货号 TMAB-07032

Anti-HIF1AN Antibody (8C810) 是一种 Rabbit 抗体，靶向 HIF1AN。Anti-HIF1AN Antibody (8C810) 可用于 WB,IHC-P,IHC-Fr,ICC/IF,IF。

规格价格库存数量
25 μL
¥ 795
5日内发货
50 μL
¥ 1,390
5日内发货
100 μL
¥ 2,480
5日内发货
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产品介绍

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产品描述
Anti-HIF1AN Antibody (8C810) is a Rabbit antibody targeting HIF1AN. Anti-HIF1AN Antibody (8C810) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.
Ig Type
IgG
克隆号
8C810
反应种属
Human
应用WBIHC-PIHC-FrICC/IFIF
推荐剂量
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; ICC/IF: 1:50-200; IF: 1:50-200
抗体种类
Monoclonal
宿主来源Rabbit
亚细胞定位Nucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages.
构建方式Recombinant Antibody
纯化方式Protein A purified
性状Liquid
缓冲液10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
研究背景Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins.
抗原信息
免疫原
A synthesized peptide: human HIF 1 alpha inhibitor
抗原种属
Human
基因名称
HIF1AN
基因ID
55662
蛋白名称
Hypoxia-inducible factor 1-alpha inhibitor
Uniprot ID
Q5W147
功能
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.
化学信息
分子量Theoretical: 40 kDa. Actual: 40 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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