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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HIF1AN Antibody (1I6)

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货号 TMAB-07031

Anti-HIF1AN Antibody (1I6) 是一种 Mouse 抗体，靶向 HIF1AN。Anti-HIF1AN Antibody (1I6) 可用于 WB,ICC/IF。

Anti-HIF1AN Antibody (1I6)

Anti-HIF1AN Antibody (1I6)

一键复制产品信息
Rating icon 还可以
货号 TMAB-07031

Anti-HIF1AN Antibody (1I6) 是一种 Mouse 抗体，靶向 HIF1AN。Anti-HIF1AN Antibody (1I6) 可用于 WB,ICC/IF。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,960
5日内发货
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产品介绍

生物活性
产品描述
Anti-HIF1AN Antibody (1I6) is a Mouse antibody targeting HIF1AN. Anti-HIF1AN Antibody (1I6) can be used in WB,ICC/IF.
Ig Type
IgG1, k
克隆号
1I6
反应种属
Human
应用WBICC/IF
推荐剂量
WB: 1:1000-5000; ICC/IF: 1:50-200
抗体种类
Monoclonal
宿主来源Mouse
亚细胞定位Nucleus. Cytoplasm. Cytoplasm, perinuclearregion. Note=Mainly cytoplasmic localization, but interaction withNOTCH1 results in nuclear localization and interaction with ABPA3results in perinuclear localization in macrophages.
构建方式Hybridoma Monoclonal Antibody
纯化方式Protein G purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景HIF1AN (Hypoxia inducible factor 1 alpha inhibitor) is a corepressor that interacts with hypoxia inducible factor 1 (HIF1) alpha and the von Hippel Lindau tumor suppressor protein to mediate repression of HIF1 transcriptional activity.
抗原信息
免疫原
KLH conjugated synthetic peptide: human HIF1AN
抗原种属
Human
基因名称
HIF1AN
基因ID
55662
蛋白名称
Hypoxia-inducible factor 1-alpha inhibitor
Uniprot ID
Q5W147
功能
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.
化学信息
分子量Theoretical: 38 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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