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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HIF1A Polyclonal Antibody

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货号 TMAB-07030

Anti-HIF1A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HIF1A。Anti-HIF1A Polyclonal Antibody 可用于 ICC/IF。

Anti-HIF1A Polyclonal Antibody

Anti-HIF1A Polyclonal Antibody

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Rating icon 还可以
货号 TMAB-07030

Anti-HIF1A Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HIF1A。Anti-HIF1A Polyclonal Antibody 可用于 ICC/IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,965
5日内发货
200 μL
¥ 2,795
5日内发货
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产品介绍

生物活性
产品描述
Anti-HIF1A Polyclonal Antibody is a Rabbit antibody targeting HIF1A. Anti-HIF1A Polyclonal Antibody can be used in ICC/IF.
Ig Type
IgG
反应种属
Human
应用ICC/IF
推荐剂量
ICC/IF: 1:50-200
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm. Nucleus.
组织特异性Expressed in most tissues with highest levels in kidney and heart. Overexpressed in the majority of common human cancers and their metastases, due to the presence of intratumoral hypoxia and as a result of mutations in genes encoding oncoproteins and tumor suppressors.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Hypoxia-inducible factor 1-alpha (HIF-1α) plays a particularly crucial role in maintaining normal physiological functions under hypoxic conditions and is also significantly involved in pathological processes such as tumor growth and neuronal apoptosis. HIF-1α regulates the expression levels of numerous downstream genes. In mammalian cells, HIF is induced under hypoxic stress conditions. As a transcription factor, HIF stabilizes cells in response to hypoxia.
抗原信息
免疫原
Recombinant Protein: human HIF-1 Alpha protein
抗原种属
Human
基因名称
HIF1A
基因ID
3091
蛋白名称
Hypoxia-inducible factor 1-alpha
Uniprot ID
Q16665
功能
Functions as a master transcriptional regulator of theadaptive response to hypoxia. Under hypoxic conditions activatesthe transcription of over 40 genes, including, erythropoietin,glucose transporters, glycolytic enzymes, vascular endothelialgrowth factor, and other genes whose protein products increaseoxygen delivery or facilitate metabolic adaptation to hypoxia.Plays an essential role in embryonic vascularization, tumorangiogenesis and pathophysiology of ischemic disease. Binds to coreDNA sequence 5'-[AG]CGTG-3' within the hypoxia response element(HRE) of target gene promoters. Activation requires recruitment oftranscriptional coactivators such as CREBPB and EP300. Activity isenhanced by interaction with both, NCOA1 or NCOA2. Interaction withredox regulatory protein APEX seems to activate CTAD andpotentiates activation by NCOA1 and CREBBP.
化学信息
分子量Theoretical: 92 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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