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顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HES3 Polyclonal Antibody

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货号 TMAB-06991

Anti-HES3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HES3。Anti-HES3 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-HES3 Polyclonal Antibody

Anti-HES3 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06991

Anti-HES3 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HES3。Anti-HES3 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,960
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍

生物活性
产品描述
Anti-HES3 Polyclonal Antibody is a Rabbit antibody targeting HES3. Anti-HES3 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,Sheep)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Nuclear.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景The Drosophila hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.
抗原信息
免疫原
KLH conjugated synthetic peptide: human HES3
抗原种属
Human
基因名称
HES3
基因ID
390992
蛋白名称
Transcription factor HES-3
Uniprot ID
Q5TGS1
功能
HES3 is a member of the homeobox family of transcription factors. HES3 is expressed in undifferentiated embryonic stem (ES) cells and is also a target of the ES cell-specific network of transcription factors. It is also expressed in neural stem cells as well as the adult subventricular zone, a restricted site in the adult CNS that sustains stem cells. It is involved in the Notch signalling pathway.
化学信息
分子量Theoretical: 20 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

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