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Anti-HER3/ERBB3 Antibody-PE (5O888)
还可以产品编号 TMAY-00451P
Anti-HER3/ERBB3 Antibody-PE (5O888) 是一种 PE-conjugated Mouse 抗体，靶向 HER3/ERBB3。Anti-HER3/ERBB3 Antibody-PE (5O888) 可用于 FCM。
Anti-HER3/ERBB3 Antibody-PE (5O888)
Anti-HER3/ERBB3 Antibody-PE (5O888)
还可以产品编号 TMAY-00451P
Anti-HER3/ERBB3 Antibody-PE (5O888) 是一种 PE-conjugated Mouse 抗体，靶向 HER3/ERBB3。Anti-HER3/ERBB3 Antibody-PE (5O888) 可用于 FCM。
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产品介绍
生物活性
偶联与修饰
抗原信息
| 产品描述 | Anti-HER3/ERBB3 Antibody-PE (5O888) is a PE-conjugated Mouse antibody targeting HER3/ERBB3. Anti-HER3/ERBB3 Antibody-PE (5O888) can be used in FCM. |
| Ig Type | Monoclonal Mouse IgG1 |
| 克隆号 | 5O888 |
| 交叉反应 | Human |
| 验证活性 | Flow cytometric analysis of anti-Human ErbB3 on MCF-7 cells. |
| 应用 | FCM |
| 推荐剂量 | 5 μl/Test, 0.1 mg/ml |
| 抗体种类 | Monoclonal |
| 宿主来源 | Mouse |
| 构建方式 | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human ErbB3 / HER3 (rh ErbB3 / HER3; TMPY-01389; NP_001973.2; Met1-Thr643) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| 纯化方式 | Protein A |
| 性状 | Liquid |
| 缓冲液 | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| 研究背景 | ErbB3, also known as Her3(human epidermal growth factor receptor3), is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound glycoprotein has a neuregulin binding domain but has not an active kinase domain., and therefore can not mediate the intracellular signal transduction through protein phosphorylation. However, its heterodimer with ErbB2 or other EGFR members responsible for tyrosine phosphorylation forms a receptor complex with high affinity, and initiates the related pathway which lead to cell proliferation or differentiation. ErbB3 has been shown to implicated in numerous cancers, including prostate, bladder, and breast tumors. This protein has different isoforms derived from alternative splicing variants, and among which, the secreted isoform lacking the intermembrane region modulates the activity of membrane-bound form.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
| 偶联 | PE |
| 其他可选修饰符 | Unconjugated |
| 可提供抗体种类 | 2 |
| 免疫原 | Recombinant Human ErbB3 / HER3 protein (TMPY-01389) |
| 抗原种属 | Human |
| 研究领域 | Cancer Drug Targets, Receptor Tyrosine Kinases (RTKs) |
存储&运输
| 储存方式 | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| 运输方式 | Shipping with blue ice. |
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比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
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