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Anti-Hephaestin Polyclonal Antibody

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货号 TMAB-06980

Anti-Hephaestin Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Hephaestin。Anti-Hephaestin Polyclonal Antibody 可用于 WB。

Anti-Hephaestin Polyclonal Antibody

Anti-Hephaestin Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06980

Anti-Hephaestin Polyclonal Antibody 是一种 Rabbit 抗体,靶向 Hephaestin。Anti-Hephaestin Polyclonal Antibody 可用于 WB。

规格价格库存数量
50 μL
¥ 1,165
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,780
5日内发货
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产品介绍


生物活性
产品描述
Anti-Hephaestin Polyclonal Antibody is a Rabbit antibody targeting Hephaestin. Anti-Hephaestin Polyclonal Antibody can be used in WB.
Ig Type
IgG
反应种属
Human,Mouse (predicted:Rat)
应用WB
推荐剂量
WB: 1:500-2000
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Membrane; Single-pass type I membrane protein (Potential).
组织特异性Detected in breast, colon, bone trabecular cells and fibroblasts.
构建方式Hybridoma Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景Hephaestin is a single-pass type I membrane protein that belongs to the multicopper oxidase family of proteins. Hephaestin, a copper-dependant ferroxidase protein, is crucial for iron exiting intestinal enterocytes into the circulation. It mediates the movement of iron across the basolateral membrane in conjunction with ferroportin 1. This is an important link between iron and copper metabolism in mammalian systems, as copper deficiency leads to reduced hephaestin and reduced iron absorption resulting in anemia. Hephaestin can bind six copper ions per monomer and is regulated by the homeobox transcription factor CDX2. Increased levels of iron leads to an increase in CDX2 expression and thus Hephaestin. Hephaestin is primarily detected in the intestine, but is also expressed in colon, breast, bone trabecural cells and fibroblasts.
抗原信息
免疫原
KLH conjugated synthetic peptide: human Hephaestin
抗原种属
Human
基因名称
HEPH
基因ID
蛋白名称
Hephaestin
Uniprot ID
功能
May function as a ferroxidase for ferrous (II) to ferric ion (III) conversion and may be involved in copper transport and homeostasis. Implicated in iron homeostasis and may mediate iron efflux associated to ferroportin 1.
化学信息
分子量Theoretical: 128 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

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