Anti-Hepcidin/HAMP Polyclonal Antibody is a Rabbit antibody targeting Hepcidin/HAMP. Anti-Hepcidin/HAMP Polyclonal Antibody can be used in IHC-P,IHC-Fr,ICC/IF,IF,ELISA.

IgG

(predicted:Mouse,Rat)

IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500; ELISA: 1:5000-10000

Polyclonal

KLH conjugated synthetic peptide: rat Hepcidin

Rat

HAMP

Hepcidin

Erythrocytes,Serum Proteins,Vitamins / minerals,Vitamins / Minerals

Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages.
Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa.
Involvement in disease;Defects in HAMP are the cause of hemochromatosis type 2B (HFE2B); also known as juvenile hemochromatosis (JH). HFE2B is a disorder of iron metabolism with excess deposition of iron in the tissues, bronze skin pigmentation, hepatic cirrhosis, arthropathy and diabetes. The most common symptoms of hemochromatosis type 2 at presentation are hypogonadism and cardiomyopathy.