购物车
全部删除
  • TargetMol
    您的购物车当前为空
前往下单页继续购物
顶部产品介绍抗原信息化学信息储存和溶解信息计算器

Anti-HECW1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06964

Anti-HECW1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HECW1。Anti-HECW1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

Anti-HECW1 Polyclonal Antibody

Anti-HECW1 Polyclonal Antibody

一键复制产品信息
Rating icon 还可以
货号 TMAB-06964

Anti-HECW1 Polyclonal Antibody 是一种 Rabbit 抗体，靶向 HECW1。Anti-HECW1 Polyclonal Antibody 可用于 IHC-P,IHC-Fr,IF。

规格价格库存数量
50 μL
¥ 1,175
5日内发货
100 μL
¥ 1,970
5日内发货
200 μL
¥ 2,790
5日内发货
库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单
大包装 & 定制
加入购物车
TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。
实验操作小课堂
常见问题解答
查看更多
资源下载:
产品操作手册

产品介绍

生物活性
产品描述
Anti-HECW1 Polyclonal Antibody is a Rabbit antibody targeting HECW1. Anti-HECW1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Ig Type
IgG
反应种属
Rat (predicted:Human,Mouse,Cow,Chicken,Dog)
应用IHC-PIHC-FrIF
推荐剂量
IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
抗体种类
Polyclonal
宿主来源Rabbit
亚细胞定位Cytoplasm.
组织特异性Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
构建方式Polyclonal Antibody
纯化方式Protein A purified
性状Liquid
缓冲液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
浓度1mg/ml
研究背景NEDL1 is a 1,606 amino acid cytoplasmic protein predominantly expressed in neurons of adult and fetal brain. NEDL1 functions as an E3 ubiquitin-protein ligase that, characteristic of E3 ligase proteins, accepts ubiquitin (in the form of a thioester) from an E2 ubiquitin-conjugating enzyme and transfers that ubiquitin residue to substrates targeted for degradation. NEDL1 mediates ubiquitination and subsequent degradation of Dvl-1 and targets mutant SOD-1. NEDL1 forms cytotoxic aggregates with Dvl, TRAP-?and mutant SOD1 that lead to motor neuron death in FALS (familial amyotrophic lateral sclerosis). individuals affect by FALS (also known as Lou Gehrig's disease) experience muscle weakness and atrophy throughout the body. FALS is caused by the degeneration of upper and lower motor neurons resulting in loss of signal to muscles.
抗原信息
免疫原
KLH conjugated synthetic peptide: human HECW1
抗原种属
Human
基因名称
HECW1
基因ID
23072
蛋白名称
E3 ubiquitin-protein ligase HECW1
Uniprot ID
Q76N89
功能
E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS). Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS.
化学信息
分子量Theoretical: 179 kDa.
储存&溶解度
储存方式Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
运输方式Shipping with blue ice.
存储store at low temperature | -20°C for 1 year

计算器

  • 稀释 计算器
Related Tags: buy Anti-HECW1 Polyclonal Antibody | purchase Anti-HECW1 Polyclonal Antibody | Anti-HECW1 Polyclonal Antibody cost | order Anti-HECW1 Polyclonal Antibody | Anti-HECW1 Polyclonal Antibody molecular weight